反応 #317749

反応方程式

ethyl 7-nitroindole-2-carboxylate

ammonia

→

7-nitro-1H-indole-2-carboxamide

反応条件

後処理

1. 1
   ろ過The reaction medium is filtered over sintered glass
2. 2
   その他The yellow solid obtained
3. 3
   洗浄is washed with water and with cyclohexane
4. 4
   その他dried under vacuum

実験手順

A suspension of 133 mg (0.57 mmol) of ethyl 7-nitroindole-2-carboxylate in 3.84 ml of 28% aqueous ammonia is heated at 50° C. for 18 h in a stoppered glass tube. The reaction medium is filtered over sintered glass. The yellow solid obtained is washed with water and with cyclohexane and then dried under vacuum. 70 mg of 7-nitro-1H-indole-2-carboxamide are obtained in the form of a yellow solid.

出典