反応 #3172

反応方程式

3(3,4,5-trifluorophenyl)thiophene

1-bromo-2,4-difluorobenzene

1-bromo-3,4,5-trifluorobenzene

→

pure product

収率 97.0%

3(2,4-difluorophenyl)thiophene

収率 97.0%

反応条件

後処理

1. 1
   その他the coupling reaction mixture
2. 2
   温度was heated
3. 3
   温度to reflux in an oil bath for 10 hours
4. 4
   温度to being heated in an oil bath for 0.5 hour
5. 5
   workup.STIRRINGwith periodically stirring)
6. 6
   その他No further purification
7. 7
   その他by recrystallization

実験手順

The same procedures set forth above in Example (1)(a) for synthesizing 3(3,4,5-trifluorophenyl)thiophene were followed, with the exception that 1-bromo-2,4-difluorobenzene was substituted for 1-bromo-3,4,5-trifluorobenzene as the 1-bromo-substituted fluorobenzene, and the coupling reaction mixture was heated to reflux in an oil bath for 10 hours with stirring at 80° C. (as opposed to being heated in an oil bath for 0.5 hour with periodically stirring). No further purification by recrystallization was required to obtain a 97 to 98% pure product.

出典