反応 #316939

反応方程式

2-thiophencarboxylic acid hydrazide

benzyl isothiocyanate

→

N-benzyl-2-(thien-2-ylcarbonyl)hydrazinecarbothioamide

収率 89.3%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他the reaction vessel was removed from the heat source
2. 2
   ろ過The resulting crystals were collected by vacuum filtration
3. 3
   洗浄washed with diethyl ether
4. 4
   その他air-dried

実験手順

To a hot solution of 2-thiophencarboxylic acid hydrazide (5.0 g, 35 mmol) in acetonitrile (80 mL) was added neat benzyl isothiocyanate (4.7 mL, 35 mmol) via syringe. When the solvent started to boil, the reaction vessel was removed from the heat source and allowed to cool to room temperature. The resulting crystals were collected by vacuum filtration, washed with diethyl ether and air-dried to yield N-benzyl-2-(thien-2-ylcarbonyl)hydrazinecarbothioamide (9.11 g; 89%; (M+H)+−292.2).

出典