反応 #316575

反応方程式

7-bromo-4-tert-butyl-4,5-dihydropyrrolo[1,2-a]quinoxaline

2,4-dimethoxybenzoyl chloride

→

7-Bromo-4-tert-butyl-5-(2,4-dimethoxybenzoyl)-4,5-dihydropyrrolo[1,2-a]quinoxaline

反応条件

後処理

1. 1
   その他The product was purified via Biotage Horizon® (25S, silica, gradient from 5% EtOAc/hexane to 40% EtOAc/hexane)
2. 2
   その他isolated as a white foam

実験手順

7-Bromo-4-tert-butyl-5-(2,4-dimethoxybenzoyl)-4,5-dihydropyrrolo[1,2-a]quinoxaline was prepared from 7-bromo-4-tert-butyl-4,5-dihydropyrrolo[1,2-a]quinoxaline (see Example 114, Step 1) and 2,4-dimethoxybenzoyl chloride according to the procedure of Example 106, Step 2. The product was purified via Biotage Horizon® (25S, silica, gradient from 5% EtOAc/hexane to 40% EtOAc/hexane) and isolated as a white foam. MS (ESI) m/z 469/471 ([M+H]+); HRMS: calcd for C24H25BrN2O3, 468.1049; found (ESI+), 469.11175.

出典