反応 #316252

反応方程式

4-(5,6-Dimethyl-[2,2′]bipyridin-3-yloxy)-6-methoxy-quinolin-7-ol

compound 338

4-(5,6-Dimethyl-[2,2′]bipyridin-3-yloxy)-6-methoxy-quinolin-7-ol

Potassium carbonate

4-bromo-1-butanol

Water

→

title compound

収率 48.4%

4-[4-(5,6-Dimethyl-[2,2′]bipyridin-3-yloxy)-6-methoxy-quinolin-7-yloxy]-butan-1-ol

収率 48.4%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   抽出the mixture was extracted with ethyl acetate
2. 2
   洗浄The ethyl acetate layer was then washed with saturated brine
3. 3
   乾燥was dried over anhydrous sodium sulfate
4. 4
   その他The solvent was removed by distillation under the reduced pressure
5. 5
   その他the residue was purified by thin layer chromatography

実験手順

4-(5,6-Dimethyl-[2,2′]bipyridin-3-yloxy)-6-methoxy-quinolin-7-ol (compound 338) (45 mg) was suspended in N,N-dimethylformamide (4 ml). Potassium carbonate (50 mg) and 4-bromo-1-butanol (55 mg) were added to the suspension, and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was then washed with saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using chloroform-acetone to give the title compound (26 mg, yield 48%).

出典