反応 #316189

反応方程式

3-[7-Hydroxy-6-methoxy-quinolin-4-yloxy]-2-methyl-[1,8]naphthyridine

Potassium carbonate

4-bromo-1-butanol

→

title compound

収率 35.0%

4-[6-Methoxy-4-(2-methyl-[1,8]naphthyridin-3-yloxy)-quinolin-7-yloxy]-butan-1-ol

収率 35.0%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   その他to prepare a solution
2. 2
   その他The solvent was removed by distillation under the reduced pressure
3. 3
   workup.ADDITIONWater was then added to the residue
4. 4
   抽出the mixture was extracted with chloroform
5. 5
   洗浄The chloroform layer was washed with saturated brine
6. 6
   乾燥was dried over anhydrous sodium sulfate
7. 7
   その他The solvent was removed by distillation under the reduced pressure
8. 8
   その他the residue was purified by thin layer chromatography

実験手順

3-[7-Hydroxy-6-methoxy-quinolin-4-yloxy]-2-methyl-[1,8]naphthyridine (45 mg) was dissolved in N,N-dimethylformamide (2 ml) to prepare a solution. Potassium carbonate (56 mg) and 4-bromo-1-butanol (62 mg) were added to the solution, and the mixture was stirred at room temperature overnight. The solvent was removed by distillation under the reduced pressure. Water was then added to the residue, and the mixture was extracted with chloroform. The chloroform layer was washed with saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by thin layer chromatography using chloroform-acetone to give the title compound (19 mg, yield 35%).

出典