反応 #315786

反応方程式

4-Chloro-6,7-dimethoxyquinoline

ethyl salicylate

→

title compound

収率 63.3%

Ethyl 2-[(6,7-dimethoxy-4-quinolyl)oxy]benzoate

収率 63.3%

溶媒

o-dichlorobenzene

反応条件

後処理

1. 1
   温度The reaction solution was cooled to room temperature
2. 2
   その他the solvent was removed by distillation under the reduced pressure
3. 3
   workup.ADDITIONWater was then added to the residue
4. 4
   抽出the mixture was extracted with chloroform
5. 5
   洗浄The chloroform layer was washed with water
6. 6
   乾燥was dried over anhydrous sodium sulfate
7. 7
   その他The solvent was removed
8. 8
   workup.DISTILLATIONby distillation under the reduced pressure
9. 9
   その他the residue was purified by column chromatography

実験手順

4-Chloro-6,7-dimethoxyquinoline (100 mg), ethyl salicylate (336 mg), and 4-dimethylaminopyridine (244 mg) were suspended in o-dichlorobenzene (1 ml), and the suspension was stirred at 120° C. overnight. The reaction solution was cooled to room temperature, and the solvent was removed by distillation under the reduced pressure. Water was then added to the residue, and the mixture was extracted with chloroform. The chloroform layer was washed with water and was dried over anhydrous sodium sulfate. The solvent was removed therefrom by distillation under the reduced pressure, and the residue was purified by column chromatography using acetone-hexane to give the title compound (100 mg, yield 56%).

出典