反応 #315322

反応方程式

6-bromo-1-hexanol

dihydropyran

→

6-bromo-1-(tetrahydropyranyloxy)hexane

収率 91.1%

反応条件

後処理

1. 1
   温度cooled to 5° C. or less
2. 2
   その他were dripped at a temperature of 10° C. or less
3. 3
   その他a reaction
4. 4
   その他Residues obtained by this reaction
5. 5
   その他were purified by silica gel column with hexane/IPE (diisopropylether)=5/1

実験手順

First, 197.8 g (1.09 mol) of 6-bromo-1-hexanol were fed into a 500 mL reactor vessel and cooled to 5° C. or less, and further 102.1 g (1.21 mol) of dihydropyran were dripped at a temperature of 10° C. or less. After completion of dripping, the mixture was warmed to room temperature to carry out a reaction under stirring for one hour. Residues obtained by this reaction were purified by silica gel column with hexane/IPE (diisopropylether)=5/1, and thus 263.4 g of 6-bromo-1-(tetrahydropyranyloxy)hexane were obtained. The yield was 90.9%. Formula (26) below shows the reaction formula of the step 1.

出典