反応 #3150

反応方程式

water

sodium

p-fluoronitro benzene

2,2,2-trifluoro ethanol

→

p-(2,2,2-trifluoroethoxy) nitrobenzene

収率 62.0%

反応条件

後処理

1. 1
   workup.ADDITIONwas dropped
2. 2
   温度refluxed for 4 hours
3. 3
   その他precipitated solids
4. 4
   洗浄were washed with water
5. 5
   その他dried

実験手順

Under a nitrogen atmosphere, 10.1 g (0.44 mol) of sodium was dissolved in 200 ml of 2,2,2-trifluoro ethanol in 300 ml of a three-necked flask, to which 40 ml (0.38 mol) of p-fluoronitro benzene was dropped and refluxed for 4 hours. After cooling to a room temperature, water was poured (about 1 liter), and precipitated solids were washed with water and dried, to obtain p-(2,2,2-trifluoroethoxy) nitrobenzene (yield: 62%; and melting point: 76.5° C.).

出典