反応 #314457

反応方程式

6-fluoroindol

4-piperidone monohydrate hydrochloride

→

6-fluoro-3-piperidin-4-yl-1H-indole

収率 51.0%

反応条件

後処理

1. 1
   その他This compound was prepared
2. 2
   その他for 1 hour

実験手順

This compound was prepared following the procedure described in Example 1 (steps A and B) starting with 1 g (7.4 mmol) of 6-fluoroindol and 2.84 g (18.5 mmol) of 4-piperidone monohydrate hydrochloride. In this case, the hydrogenation step took place for 1 hour at 2 bar and the catalyst used was platinum (IV) oxide. 0.640 g (51% yield) of 6-fluoro-3-piperidin-4-yl-1H-indole were obtained.

出典