反応 #314249

反応方程式

1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide

4-chlorophenylmagnesium bromide

→

1-(6-Bromo-pyridin-2-ylmethyl)-3-(4-chloro-benzoyl)-1H-quinolin-4-one

溶媒

THF

反応条件

実験手順

Experimental conditions analogous to those described for Step 6 of Example 60 from 150 mg (0.37 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid methoxy-methyl-amide in 3 mL THF and 0.82 mL 1M 4-chlorophenylmagnesium bromide. Yield: 73 mg of a white solid. LC-MSD, m/z for C22H14BrClN2O2 [M+H]+=453.0, 455.0; HPLC retention time: 2.6 min.

出典