反応 #3142

反応方程式

4,6-dihydroxy-2-methylpyrimidinamine

sodium ethoxide

sodium

Acetamidine hydrochloride

diethyl malonate

→

4,6-dihydroxy-2-methylpyrimidine

溶媒

ethanol

反応条件

後処理

1. 1
   温度the reaction mixture heated

実験手順

The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.

出典