反応 #313981

反応方程式

1,4-diaminobenzene

ethyl isocyanate

potassium carbonate

→

4-(ethylaminocarbonylamino)aniline

収率 62.0%

溶媒

THF

反応条件

後処理

1. 1
   その他The reaction mixture was partitioned in 1N HCl solution (80 mL)
2. 2
   抽出The aqueous layer was extracted with ethyl acetate (4×80 mL)
3. 3
   その他The combined organic layers was dried
4. 4
   その他evaporated
5. 5
   その他recrystallized from MeOH/CH2Cl2/hexanes

実験手順

A mixture of 1,4-diaminobenzene (4 g, 37 mmol), ethyl isocyanate (1 mL, 12.6 mmol) and potassium carbonate (8.72 g, 63 mmol) in THF (20 mL) was stirred at room temperature overnight. The reaction mixture was partitioned in 1N HCl solution (80 mL) and ethyl acetate (80 mL). The aqueous layer was extracted with ethyl acetate (4×80 mL). The combined organic layers was dried, evaporated, recrystallized from MeOH/CH2Cl2/hexanes to give 4-(ethylaminocarbonylamino)aniline (1.4 g, 62%) as a beige solid.

出典