反応 #313455

反応方程式

water

Imidazole

ethyl 4-cyano-3-hydroxybutanoate

tert-butyl diphenyl silyl chloride

→

title compound

Ethyl 4-cyano-3-(tert-butyldiphenylsilyloxy)-butanoate

溶媒

dichloromethane

反応条件

後処理

1. 1
   workup.STIRRINGAfter stirring for 4 hours at room temperature
2. 2
   その他separated
3. 3
   抽出The aqueous layer was extracted with dichloromethane (100 ml)
4. 4
   その他The combined organic layer was evaporated

実験手順

Imidazole (6.5 g, 0.095 mol) was added to a chilled solution (−5 to −10° C.) of ethyl 4-cyano-3-hydroxybutanoate (10 g, 0.063 mol) in dichloromethane (100 ml) under stirring, followed by tert-butyl diphenyl silyl chloride (15.7 g, 0.057 mol). After stirring for 4 hours at room temperature, water (250 ml) was added to the reaction mixture and layers separated. The aqueous layer was extracted with dichloromethane (100 ml) and combined with the organic layer. The combined organic layer was evaporated to give title compound.

出典