反応 #312750

反応方程式

N-BOC-3-pyrrolidone

N,N-dimethylformamide-dimethylacetal

→

crude title compound

収率 90.0%

3-[1-Dimethylamino-meth-(Z)-ylidene]-4-oxo-pyrrolidine-1-carboxylic acid tert.-butyl ester

収率 90.0%

溶媒

N,N-dimethylformamide

反応条件

後処理

1. 1
   その他The reaction mixture was quenched by addition of 50 ml water
2. 2
   抽出extracted 3 times with ethyl acetate
3. 3
   乾燥The extract was dried over magnesium sulfate
4. 4
   濃縮concentrated

実験手順

A solution of 13.5 mmol N-BOC-3-pyrrolidone and 13.5 mmol N,N-dimethylformamide-dimethylacetal in 50 ml N,N-dimethylformamide was hold overnight at 60° C. The reaction mixture was quenched by addition of 50 ml water and extracted 3 times with ethyl acetate. The extract was dried over magnesium sulfate and concentrated to give the crude title compound as a yellowish oil. Yield=90%. MS (m/e): 241.4 ([M+H]+, 100%).

出典