反応 #312605

反応方程式

1,1,1-Tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1H)-one

alcohol

Methyl 5-[({2-[4-(1-hydroxyhexyl)phenyl]-1,1 -dioxidoisothiazolidin-3-yl}oxy)methyl]thiophene-2-carboxylate

→

ketone

収率 101.2%

Methyl 5-({[2-(4-hexanoylphenyl)-1,1-dioxidoisothiazolidin-3-yl]oxy}methyl)thiophene-2-carboxylate

収率 101.2%

溶媒

CH2Cl2

CH2Cl2

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   濃縮The filtrate was concentrated in vacuo and purification of the residue by flash column chromatography (silica gel, 1:1 hex/EtOAc)

実験手順

1,1,1-Tris(acetyloxy)-1,1-dihydro-1,2-benziodoxol-3-(1H)-one (44 mg, 0.104 mmol) was added to a solution of the alcohol 14 (42 mg, 0.087 mmol) in CH2Cl2 (2 mL) at 23° C. After stirring for 16 h the reaction mixture with CH2Cl2 and filtered. The filtrate was concentrated in vacuo and purification of the residue by flash column chromatography (silica gel, 1:1 hex/EtOAc) gave 41 mg (98%) of the ketone 16.

出典