反応 #312604

反応方程式

Dioxide

3-(Benzyloxymethyl)-isothiazolidine 1,1-dioxide

→

hydroxyl-dioxide

収率 67.0%

3-(Hydroxymethyl)-isothiazolidine 1,1-dioxide

収率 67.0%

溶媒

—

IMS

iPrOAc

iPrOAc

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   workup.WAITAfter a further 4 days the reaction was
3. 3
   ろ過The palladium catalyst was filtered under nitrogen on a bed of celite, which
4. 4
   洗浄was subsequently washed with IMS (250 mL) and iPrOAc (250 mL)
5. 5
   濃縮The filtrate and washings were concentrated
6. 6
   その他to give the crude product as an oil (26.26 g)
7. 7
   その他The oil was purified by flash column chromatography (silica gel, DCM/methanol (9:1))

実験手順

Dioxide 7 (40 g, 0.17 mol) was placed in the glass liner within a 2 L Parr hydrogenator and dissolved in a mixture of IMS (150 ml) and iPrOAc (150 ml). A suspension of 5% palladium on carbon (Johnson Matthey type 392, 18 g) in iPrOAc (50 mL) was added and the suspension stirred under a hydrogen atmosphere of 70 psi for 3 days. After this time an NMR IPC was carried out that showed approx 15% benzylated material still present. After a further 4 days the reaction was 94% complete and it was decided to stop the hydrogenolysis. The palladium catalyst was filtered under nitrogen on a bed of celite, which was subsequently washed with IMS (250 mL) and iPrOAc (250 mL). The filtrate and washings were concentrated to give the crude product as an oil (26.26 g). The oil was purified by flash column chromatography (silica gel, DCM/methanol (9:1)) yielding 16.65 g (67%) of the hydroxyl-dioxide 8 as a white solid.

出典