反応 #310546

反応方程式

4-hydroxy-6-methyl-2-trichloromethylpyrimidine

triethylamine

ether

isopropyl chloroformate

→

product

収率 58.9%

4-Isopropoxycarbonyloxy-6-Methyl-2-Trichloromethylpyrimidine

収率 58.9%

溶媒

benzene

反応条件

後処理

1. 1
   温度The reaction mixture was refluxed one hour
2. 2
   ろ過filtered
3. 3
   その他rotary evaporated
4. 4
   その他to give a yellow oil
5. 5
   workup.DISTILLATIONThe oil was distilled (bp1.2 mm 120° C.)
6. 6
   その他to give a cloudy yellow oil
7. 7
   ろ過filtered
8. 8
   その他the solvent removed

実験手順

To a solution of 3.0 g (0.013 mole) 4-hydroxy-6-methyl-2-trichloromethylpyrimidine, 1.4 g (0.013 mole) triethylamine, and 75 ml ether was added 1.6 g (0.013 mole) isopropyl chloroformate. The reaction mixture was refluxed one hour, filtered, and rotary evaporated to give a yellow oil. The oil was distilled (bp1.2 mm 120° C.) to give a cloudy yellow oil. This was taken up in benzene, filtered, and the solvent removed leaving 2.4 g (57% yield) of product. The structure was confirmed via infrared and elemental analysis.

出典