反応 #310542

反応方程式

4-hydroxy-6-methyl-2-trichloromethylpyrimidine

triethylamine

phenyl chloroformate

→

thick oily residue

収率 94.9%

6-Methyl-4-Phenoxycarbonyloxy-2-Trichloromethylpyrimidine

収率 94.9%

溶媒

ether

反応条件

後処理

1. 1
   温度The solution refluxed on addition
2. 2
   その他a precipitate formed
3. 3
   ろ過filtered
4. 4
   その他the filtrate rotary evaporated

実験手順

To 5.6 g (0.02 mole) 4-hydroxy-6-methyl-2-trichloromethylpyrimidine, 2.0 g (0.02 moles) triethylamine, and 100 ml ether was added 3.2 g (0.07 mole) phenyl chloroformate. The solution refluxed on addition and a precipitate formed. This was stirred 0.5 hour, filtered, and the filtrate rotary evaporated to give 6.6 g (76% yield) thick oily residue. Extraction with ligroin gave, on cooling of the extract, 3.7 g pure product as a viscous oil. The structure was confirmed via infrared and elemental analysis.

出典