反応 #309183

反応方程式

tert-butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate

tert-Butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate

NaHCO3

→

2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine

2(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine

溶媒

TFA

反応条件

後処理

1. 1
   抽出extracted with CHCl3
2. 2
   乾燥dried (Na2SO4)
3. 3
   ろ過filtered
4. 4
   濃縮concentrated under reduced pressure

実験手順

A mixture of tert-butyl [2-(4-bromophenyl)-5,8-dioxaspiro[3.4]oct-2-yl]carbamate (1-5) (3.7 g, 9.63 mmol) in TFA (20 mL) was stirred at room temperature for 1 hour. The mixture was poured into a sat. NaHCO3 solution, extracted with CHCl3, dried (Na2SO4), filtered, and concentrated under reduced pressure to give 2-(4-bromophenyl)-5,8-dioxaspiro[3.4]octan-2-amine (7-1).

出典