反応 #309036

反応方程式

water

4,5-dichloropyridazin-6-one

N,N-diisopropylethylamine

bromomethyl methyl ether

→

4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one

収率 74.8%

溶媒

methylenechloride

反応条件

後処理

1. 1
   その他at room temperature
2. 2
   濃縮was then concentrated
3. 3
   その他Purification by column chromatography (1% MeOH in CH2Cl2)

実験手順

To a stirred solution of 4,5-dichloropyridazin-6-one (5.00 g, 30.3 mmol) and N,N-diisopropylethylamine (7.92 mL, 45.5 mmol) in methylenechloride (50 mL) was added slowly, bromomethyl methyl ether (4.79 mL, 60.6 mmol) at room temperature (water-bath). The reaction was stirred for 22 h and was then concentrated. Purification by column chromatography (1% MeOH in CH2Cl2) gave 4.74 g (74.8%) of 4,5-dichloro-2-methoxymethyl-2H-pyridazin-3-one.

出典