反応 #3090

反応方程式

4-Hydroxyphenethyl alcohol

Potassium tert-butoxide

(Chloromethyl)cyclopropane

→

4-[(2-Cyclopropylmethoxy)-ethyl]-phenol

溶媒

DMSO

DMSO

反応条件

後処理

1. 1
   workup.STIRRINGThe mixture was then stirred at 50° C. for one hour
2. 2
   温度cooled to room temperature

実験手順

A reaction flask was charged with 4-Hydroxyphenethyl alcohol (1) (100 g, 0.72 mol), Potassium tert-butoxide (243 g, 2.17 mol), and 500 mL of DMSO. The mixture was stirred under nitrogen at 50° C. for 30 minutes. A solution of (Chloromethyl)cyclopropane (100 g, 1.10 mol) in 500 mL of DMSO was added dropwise to the reaction mixture. The mixture was then stirred at 50° C. for one hour and then cooled to room temperature.

出典