反応 #3074

反応方程式

amide

N-(3-cyanopropyl)-(3'-bromo-4'-methylphenyl)carboxamide

TMSN3

PPh3

DEAD

NaOH

→

5-(3'-bromo-4'-methylphenyl)tetrazole

溶媒

THF

THF

反応条件

後処理

1. 1
   濃縮concentrated
2. 2
   抽出processing by extraction

実験手順

A solution of 1.0 mmol of this amide, 4.0 mmol of TMSN3, 4.0 mmol of PPh3, and 4.0 mmol of DEAD in 4 mL of THF at 0° C. was stirred 24 h and then concentrated. The residue was mixed with 5 mL of THF and 12.0 mmol of 1N NaOH. After stirring for 24 h and processing by extraction, 5-(3'-bromo-4'-methylphenyl)tetrazole was obtained.

出典