反応 #3061

反応方程式

CO2

2-isopropylthiophenol

TMEDA

n-BuLi

→

2-mercapto-3-isopropylbenzoic acid

溶媒

cyclohexane

反応条件

後処理

1. 1
   workup.STIRRINGstirred for 16 h
2. 2
   抽出when extraction and chromatography

実験手順

To a solution of 1.0 mmol 2-isopropylthiophenol and 2.2 mmol TMEDA in 2 mL cyclohexane was added 2.2 mmol n-BuLi. Then after stirring 24 h it was added to solid CO2 and stirred for 16 h when extraction and chromatography provided 2-mercapto-3-isopropylbenzoic acid. The methyl ester of this was treated as in example 3 to provide the title compound.

出典