反応 #305458

反応方程式

1,10-decandiol

trifluoromethanesulphonic anhydride

α-hydroxyethylacrylate

triethylamine

→

Ethyl 2-[12-hydroxy-2-oxadodecyl]acrylate

収率 20.0%

溶媒

dichloromethane

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   その他stays below 5° C
2. 2
   workup.STIRRINGAfter the reaction mixture was stirred for 12 h at room temperature the solution
3. 3
   洗浄was successively washed with 2×300 ml of an aqueous sodium carbonate solution (1 n) and 1×400 ml water
4. 4
   乾燥The organic layer was dried over magnesium sulphate
5. 5
   ろ過filtered
6. 6
   workup.DISTILLATIONwas finally purified by vacuum distillation (>150° C./0.028 mbar)

実験手順

To a solution of 54.7 g trifluoromethanesulphonic anhydride in 210 ml dichloromethane a solution of 25 g (0.192 mol) α-hydroxyethylacrylate and 19.43 g (0.192 mol) triethylamine in 400 ml dichloromethane was added slowly, so that the temperature of the reaction mixture stays below 5° C. The solution was stirred for 45 min at 0° C. before it was added drop wise at room temperature to a solution of 60 g (0.344 mol) 1,10-decandiol in 400 ml dichloromethane. After the reaction mixture was stirred for 12 h at room temperature the solution was successively washed with 2×300 ml of an aqueous sodium carbonate solution (1 n) and 1×400 ml water. The organic layer was dried over magnesium sulphate and filtered. The raw product was prepurified by column chromatography on silica gel with ethyl acetate as eluens. After the raw product was stabilized with 113 mg BHT, it was finally purified by vacuum distillation (>150° C./0.028 mbar). This afforded 11.024 g (yield: 20%) of a clear, colourless product.

出典