反応 #3049

反応方程式

Water

Allyl bromide

2-t-butylphenol

potassium carbonate

→

2-(1,1-dimethylethyl)phenoxypropene

溶媒

acetone

反応条件

後処理

1. 1
   温度at reflux temperature for 50 hours
2. 2
   その他the resulting layers were separated
3. 3
   抽出The aqueous layer was extracted with 600 ml of diethyl ether
4. 4
   抽出extract
5. 5
   乾燥the resulting solution was dried over sodium sulfate overnight
6. 6
   その他After sodium sulfate removal
7. 7
   その他the solvent was evaporated
8. 8
   その他to provide

実験手順

Allyl bromide (69.2 ml), 2-t-butylphenol (122.9 ml) and potassium carbonate (121.6 g) were stirred in 265 ml of acetone at reflux temperature for 50 hours and then cooled to 35° C. Water (600 ml) was added and the resulting layers were separated. The aqueous layer was extracted with 600 ml of diethyl ether. The organic layer was combined with the aqueous layer's ether extract and the resulting solution was dried over sodium sulfate overnight. After sodium sulfate removal, the solvent was evaporated to provide, after further workup, 147 g of the subtitled intermediate.

出典