反応 #303162

反応方程式

Granisetron

hydrochloric acid

→

granisetron hydrochloride

溶媒

toluene

反応条件

後処理

1. 1
   温度heated to dissolution
2. 2
   workup.DISTILLATIONThe resulting suspension is distilled at below 80° C.
3. 3
   温度cooled to below 10° C
4. 4
   その他The solid is collected
5. 5
   その他dried

実験手順

Granisetron (60.0 g) and toluene (12 parts) are charged to a suitable reactor and heated to dissolution. Conc. hydrochloric acid (1.1 eq) is added drop wise while maintaining the temperature at 50 to 60° C. The resulting suspension is distilled at below 80° C. to ⅔ volume and cooled to below 10° C. The solid is collected and dried to provide granisetron hydrochloride (53.6-67 g).

出典