反応 #302891

反応方程式

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

Compound C7

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

sodium hydroxide

→

title compound

収率 98.9%

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine

収率 98.9%

溶媒

water

water

diethyl ether

反応条件

後処理

1. 1
   workup.ADDITIONpoured into a separatory funnel
2. 2
   抽出was extracted with two 50 mL portions of diethyl ether
3. 3
   乾燥dried with sodium sulfite
4. 4
   ろ過filtered
5. 5
   濃縮The filtrate was concentrated under reduced pressure

実験手順

A mixture of 0.36 gram (0.0012 mole) of ((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride (Compound C7) in one mL of water was added to a stirred, cold (ice water bath) mixture of 0.05 gram (0.0013 mole) of sodium hydroxide in 10 mL of water and 10 mL of diethyl ether. The reaction mixture was stirred for 10 minutes, poured into a separatory funnel and was extracted with two 50 mL portions of diethyl ether. The extracts were combined, dried with sodium sulfite and filtered. The filtrate was concentrated under reduced pressure to yield 0.31 gram of the title compound as a white solid. The NMR spectrum was consistent with the proposed structure.

出典