反応 #302890

反応方程式

2,3-dichlorobenzylamine

2-chloroethylisothiocyanate

→

title compound

収率 163.2%

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

収率 163.2%

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   その他was placed in a sealed reaction vial
2. 2
   温度to cool
3. 3
   その他a solid precipitate that had formed
4. 4
   ろ過was collected by filtration
5. 5
   洗浄The solid was rinsed with diethyl ether
6. 6
   その他was dried under reduced pressure

実験手順

A mixture of 0.5 gram (0.0028 mole) of 2,3-dichlorobenzylamine and 0.27 gram (0.0081 mole) of 2-chloroethylisothiocyanate in 10 mL of 1,4-dioxane was placed in a sealed reaction vial. The reaction mixture was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 0.68 gram of the title compound. The NMR spectrum was consistent with the proposed structure.

出典