反応 #302886

反応方程式

sodium methoxide

o-bromobenzyl bromide

toluene

water

→

1-methoxymethyl-2-bromobenzene

溶媒

methanol

methanol

反応条件

後処理

1. 1
   その他layers were separated
2. 2
   その他an organic layer was recovered
3. 3
   抽出An aqueous layer was extracted with 211 g of toluene three times
4. 4
   workup.ADDITIONthe recovered organic layer and 211 g of water were added
5. 5
   洗浄this was washed
6. 6
   濃縮concentrated

実験手順

A temperature of 59.8 g of a 28% solution of sodium methoxide in methanol was raised to 60° C., a mixture solution of 70.4 g of o-bromobenzyl bromide and 70.4 g of methanol was added dropwise, and this was retained at 60° C. for 2 hours. After the mixture was cooled to room temperature, 211 g of toluene and 211 g of water were added thereto, the mixture was stirred, and layers were separated, and an organic layer was recovered. An aqueous layer was extracted with 211 g of toluene three times, the recovered organic layer and 211 g of water were added, and this was washed, and concentrated to obtain 55.3 g of 1-methoxymethyl-2-bromobenzene.

出典