反応 #302873

反応方程式

N,N-dimethylammonium iodide

2,2-dimethyl-5-phenyl-[1,3]dioxane-4,6-dione

→

2-phenyl acrylic acid methyl ester

収率 102.7%

溶媒

methanol

反応条件

後処理

1. 1
   workup.WAITto continue over night at 65° C
2. 2
   その他the solvent was removed under reduced pressure
3. 3
   workup.ADDITIONThe residue was treated with diethyl ether
4. 4
   抽出extracted with a satured NaHCO3 solution and brine
5. 5
   乾燥dried over MgSO4
6. 6
   その他The solvent was removed under reduced pressure

実験手順

A solution of 25 g (135.1 mmol) N,N-dimethylammonium iodide and 11.91 g (54.1 mmol) 2,2-dimethyl-5-phenyl-[1,3]dioxane-4,6-dione in 585 ml abs. methanol was heated to 65° C. and the reaction was allowed to continue over night at 65° C. The reaction mixture was allowed to cool down to room temperature and the solvent was removed under reduced pressure. The residue was treated with diethyl ether, extracted with a satured NaHCO3 solution and brine and dried over MgSO4. The solvent was removed under reduced pressure and 9.01 g (quant.) of 2-phenyl acrylic acid methyl ester was isolated as a colourless oil. The compound was used without further purification.

出典