反応 #302862

ord-e4a4856015b747faa4a7eb10e50a9f34

反応方程式

CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.O=C(O)CCC(=O)O
dipalmitoylglycerol succinate
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
NCCc1c[nH]cn1
histamine
→
CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.NCCc1c[nH]cn1.O=C(O)CCC(=O)O
histamine dipalmitoylglycerol succinate

反応物

CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.O=C(O)CCC(=O)O
dipalmitoylglycerol succinate
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
NCCc1c[nH]cn1
histamine

試薬

なし

溶媒

CN(C)C=O
DMF
CN(C)C=O
DMF

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    workup.STIRRINGThe mixture is stirred overnight
  2. 2
    濃縮concentrated thoroughly in vacuum
  3. 3
    その他The residue is purified

実験手順

1.7 g of dipalmitoylglycerol succinate is dissolved in 20 ml of DMF at room temperature. The solution is added with 400 mg of carbonyldiimidazole dissolved in 20 ml of DMF. The mixture is allowed to stir for 1 hour and subsequently added with 300 mg of histamine. The mixture is stirred overnight and concentrated thoroughly in vacuum. The residue is purified using column chromatography on silica gel 60, with chloroform/methanol 10:1 being used as eluant.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08192753B2uspto-grants-2012_06