反応 #2985

反応方程式

hydrochloric acid

potassium carbonate

3-(7-methoxy-1-naphthyl)propylamine hydrochloride

acetyl chloride

→

N-[3-(7-METHOXY-1-NAPHTHYL)PROPYL]ACETAMIDE

溶媒

water

反応条件

後処理

1. 1
   その他The amine precipitates
2. 2
   workup.ADDITIONThereafter, 50 cm3 of chloroform are added
3. 3
   workup.WAITThe medium is left
4. 4
   workup.STIRRINGstirred for 15 minutes
5. 5
   抽出The aqueous phase is extracted with 3 times 50 cm3 of chloroform
6. 6
   洗浄The organic phases are washed with water
7. 7
   乾燥dried over calcium chloride
8. 8
   その他evaporated
9. 9
   その他Purification of the products
10. 10
    その他is performed either by recrystallization or by column chromatography

実験手順

After 0.005 mol (equivalent to 1.26 g) of 3-(7-methoxy-1-naphthyl)propylamine hydrochloride has been dissolved in 20 cm3 of water, 0.015 mol of potassium carbonate is added. The amine precipitates. Thereafter, 50 cm3 of chloroform are added and 0.010 mol of acetyl chloride is added dropwise. The medium is left stirring for 2 hours. It is acidified with 2N of hydrochloric acid and then stirred for 15 minutes. The aqueous phase is extracted with 3 times 50 cm3 of chloroform. The organic phases are washed with water, dried over calcium chloride and evaporated. Purification of the products is performed either by recrystallization or by column chromatography.

出典