反応 #2945

反応方程式

diketene acetone

pyrrolidine

→

title compound

収率 97.9%

1-(3-Oxobutyryl)pyrrolidine

収率 97.9%

溶媒

toluene

反応条件

後処理

1. 1
   その他as described in preparation 7
2. 2
   その他The solvent was removed in vacuo
3. 3
   その他the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%)

実験手順

9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.

出典