反応 #2901

反応方程式

ethanol

3-Furyl-4-methyl-5-oxazolyl ketone

methyllithium

sodium chloride

→

1-(3-furyl)-1-(4-methyl-5-oxazolyl)ethanol

溶媒

diethylether

反応条件

後処理

1. 1
   抽出extracted with dichloromethane
2. 2
   その他Chromatography and crystallisation

実験手順

3-Furyl-4-methyl-5-oxazolyl ketone (1 g) in dry diethylether (15 ml) at -70° C. under a nitrogen atmosphere was treated dropwise with methyllithium (1.5M solution in diethylether, 4.1 ml). After 45 minutes the reaction mixture was allowed to warm to room temperature and ethanol (2 ml) was added. The mixture was poured into saturated aqueous sodium chloride and extracted with dichloromethane. Chromatography and crystallisation then gave 1-(3-furyl)-1-(4-methyl-5-oxazolyl)ethanol identical to the material obtained in (a) above.

出典