反応 #2900

反応方程式

4-Methyl-5-thiazolecarbaldehyde

aluminium isopropoxide

sodium hydride

→

title compound

5-Methoxymethyl-4-methylthiazole

溶媒

dimethoxyethane

iodomethane

2-propanol

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   workup.DISTILLATIONDistillation

実験手順

4-Methyl-5-thiazolecarbaldehyde (J. Amer. Chem. Soc., 1982, 104, 4934-4943) was reduced using aluminium isopropoxide in 2-propanol. The resulting alcohol was treated with sodium hydride in dimethoxyethane and iodomethane was added. Distillation gave the title compound.

出典