反応 #2898

反応方程式

iodomethane

4-Bromo-3,5-dimethylpyrazole

sodium hydride

sodium hydrogen carbonate

hydrogen

→

title compound

4-Bromo-1,3,5-trimethylpyrazole

溶媒

dimethylformamide

dimethylformamide

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   その他evaporation under high vacuum
3. 3
   その他the residue was purified by column chromatography

実験手順

4-Bromo-3,5-dimethylpyrazole (10 g) in dry dimethylformamide (50 ml) was added to a stirred suspension of sodium hydride (1.8 g) in dry dimethylformamide at 0° C. When the evolution of hydrogen was complete, iodomethane (8.9 g) was added dropwise. The mixture was allowed to warm to room temperature and after 30 minutes saturated aqueous sodium hydrogen carbonate (5 ml) was added. Following evaporation under high vacuum, the residue was purified by column chromatography to give the title compound.

出典