反応 #2892

反応方程式

sodium hydroxide

3-Chloropentane-2,4-dione

propionamide

propionic acid

→

5-Acetyl-2-ethyl-4-methyloxazole

反応条件

後処理

1. 1
   抽出extracted with dichloromethane
2. 2
   洗浄The combined extracts were washed with brine
3. 3
   その他dried
4. 4
   その他the solvent removed
5. 5
   その他to leave a brown oil which
6. 6
   workup.DISTILLATIONwas purified by vacuum distillation, b.p. 70° C. at 2 mbar

実験手順

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.

出典