反応 #2876

反応方程式

N-bromosuccinimide

5-bromo-2-fluoro-benzyl alcohol

triphenyl phosphine

→

title compound

収率 96.7%

5-Bromo-2-fluoro-benzyl bromide

収率 96.7%

溶媒

THF

反応条件

後処理

1. 1
   その他The ice bath is removed
2. 2
   その他The crude product is purified by column chromatography
3. 3
   洗浄eluting with 5% EtOAc/hexanes

実験手順

To a solution of 5-bromo-2-fluoro-benzyl alcohol (3.10 g, 15.1 mmol) in 30 mL of THF at 10° C. is added triphenyl phosphine (4.10 g, 15.6 mmol) followed by N-bromosuccinimide (2.67 g, 15.0 mmol). The ice bath is removed and the resulting solution is stirred for 20 min at room temperature. The crude product is purified by column chromatography eluting with 5% EtOAc/hexanes to give the title compound (3.90 g, 14.5 mmol).

出典