反応 #2874

反応方程式

3-Bromobenzaldehyde

malonic acid

hydrochloric acid

→

title compound

収率 94.4%

3-(3-Bromophenyl)acrylic acid

収率 94.4%

溶媒

pyridine

反応条件

後処理

1. 1
   温度The reaction mixture is cooled to room temperature
2. 2
   その他the resultant precipitate is collected
3. 3
   洗浄washed with copious amounts of water
4. 4
   その他dried in a vacuum dessicator overnight

実験手順

3-Bromobenzaldehyde (10.0 g, 54 mmol), malonic acid (10.1 g, 97 mmol) and piperidine (0.267 mL, 2.7 mmol) are treated with pyridine (30 mL) and heated at 100° C. for 3.5 h. The reaction mixture is cooled to room temperature, poured into 200 ml of 20% hydrochloric acid at 0° C.; the resultant precipitate is collected, washed with copious amounts of water and dried in a vacuum dessicator overnight to afford the title compound (11.64 g, 51 mmol).

出典