反応 #2853

反応方程式

2-methoxy-ethoxymethoxy chloride

HCl

sodium borohydride

sodium hydride

2-hydroxy-5-iodo-benzaldehyde

→

title compound

収率 80.4%

5-Iodo-2-(2-methoxy-ethoxymethoxy)-benzyl alcohol

収率 80.4%

溶媒

1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

water

THF

ether

THF

反応条件

後処理

1. 1
   温度to warm to ambient temperatures
2. 2
   洗浄washed with water and saturated NaCl
3. 3
   乾燥The organic layer is dried over MgSO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated
6. 6
   その他The resulting crude material is purified by column chromatography
7. 7
   洗浄eluting with 40% EtOAc/hexanes

実験手順

To a solution of sodium hydride (1.2 g of a 60% mineral oil dispersion, 52 mmol) in 25 mL of THF at 0° C., is added 2-hydroxy-5-iodo-benzaldehyde (7.0 g, 28 mmol). To the resulting solution is added 2-methoxy-ethoxymethoxy chloride (3.4 mL, 30 mmol) and 4 mL of 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone. The solution is allowed to warm to ambient temperatures. After 45 min., the solution is cooled to -15° C. and 6 mL of a 2M solution of sodium borohydride in THF is added. The solution is stirred for 10 min. After this time, 24 mL of a 2M HCl solution in water is added. The resulting solution is diluted with ether, washed with water and saturated NaCl. The organic layer is dried over MgSO4, filtered and concentrated. The resulting crude material is purified by column chromatography eluting with 40% EtOAc/hexanes to give the title compound (7.6 g, 22.5 mmol) as a white solid.

出典