反応 #2804

反応方程式

methanesulfonic acid 2-(2-chloromethyl-phenyl)-ethyl ester

potassium t-butoxide

→

1-chloromethyl-2-vinyl-benzene

収率 82.0%

溶媒

ether

反応条件

後処理

1. 1
   抽出Add water (50 mL) and ether (150 mL), extract
2. 2
   乾燥dry (Na2SO4)
3. 3
   その他purify by silica gel chromatography (2:3 methylene chloride/pentane)

実験手順

Dissolve methanesulfonic acid 2-(2-chloromethyl-phenyl)-ethyl ester (8.8 g, 35.4 mmol) in ether (80 mL) and cool to -35° C. Add potassium t-butoxide (10 g, 89 mmol) and stir for 30 minutes. Add water (50 mL) and ether (150 mL), extract, dry (Na2SO4) and purify by silica gel chromatography (2:3 methylene chloride/pentane) to give 1-chloromethyl-2-vinyl-benzene as a colorless oil (4.43 g, 82%).

出典