反応 #2799

反応方程式

chloroacetyl chloride

N-methylmorpholine

morpholine

→

chloroacetic acid morpholine carboxamide

溶媒

dichloromethane

反応条件

後処理

1. 1
   温度Cool in an ice-bath
2. 2
   抽出Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution
3. 3
   乾燥Dry the organic layer over Na2SO4
4. 4
   ろ過filter
5. 5
   その他evaporate in vacuo

実験手順

Combine chloroacetyl chloride (2.00 mL, 25.0 mmol) and N-methylmorpholine (2.76 mL, 25.0 mmol) in dichloromethane (100 mL). Cool in an ice-bath. Add morpholine (2.19 mL, 25.0 mmol) and stir in the ice-bath for 1 hour. Warm to ambient temperature and stir for 1 hour. Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to obtain chloroacetic acid morpholine carboxamide.

出典