反応 #2624

反応方程式

fumaric acid

4-Amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide

→

title compound

収率 90.1%

4-Amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide hemifumarate

収率 90.1%

溶媒

methanol

methanol

反応条件

後処理

1. 1
   ろ過Thereafter, the thus precipitated crystals were collected by filtration
2. 2
   その他recrystallized from an ethanol-water mixture solution

実験手順

4-Amino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide (475.0 mg, 1.00 mmol) was dissolved in methanol (4.0 ml) and mixed with a methanol solution (3.0 ml) of fumaric acid (58.0 mg, 0.50 mmol) at 0° C. Thereafter, the thus precipitated crystals were collected by filtration and recrystallized from an ethanol-water mixture solution to obtain 481.0 mg (90.0%) of the title compound in a colorless powder form.

出典