反応 #2567

反応方程式

N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-4-hydroxymethyl-N-(2-methoxyphenyl)benzene sulfonamide

→

title compound

収率 81.7%

N-{2-[4-(4-Fluorobenzoyl)piperidino]ethyl}-4-formyl-N-(2-methoxyphenyl)benzene sulfonamide

収率 81.7%

溶媒

methylene chloride

methylene chloride

反応条件

後処理

1. 1
   workup.ADDITIONwas added to the suspension
2. 2
   ろ過the reaction mixture was filtered through silica gel (1 g) which
3. 3
   洗浄was further subjected to elution with ethyl acetate
4. 4
   その他the solvent was removed by evaporation

実験手順

Activated manganese dioxide (870 mg, 10.0 mmol) was suspended in methylene chloride (10 ml), and N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-4-hydroxymethyl-N-(2-methoxyphenyl)benzene sulfonamide (259 mg, 0.492 mmol) dissolved in methylene chloride (3 ml) was added to the suspension. After 30 minutes of stirring at room temperature, the reaction mixture was filtered through silica gel (1 g) which was further subjected to elution with ethyl acetate. Thereafter, the filtrate and eluate were combined, and the solvent was removed by evaporation to obtain 211 mg (81.7%) of the title compound in a colorless amorphous form.

出典