反応 #2563

反応方程式

4-(4-fluorobenzoyl)piperidine

sodium cyanoborohydride

triethylamine

sodium hydroxide

N-hydroxyethyl-4-methoxy-N-(2-methoxyphenyl)benzene sulfonamide

→

title compound

収率 20.7%

N-{2-[4-(4-Fluorobenzoyl)piperidino]ethyl}-4-methoxy-N-(2-methoxyphenyl)benzene sulfonamide

収率 20.7%

溶媒

ether

methanol

acetone

DMSO

DMSO

反応条件

後処理

1. 1
   workup.ADDITIONwas added to the reaction solution
2. 2
   抽出the mixture was extracted with ethyl acetate
3. 3
   洗浄washed with water and saturated brine
4. 4
   乾燥The resulting organic layer was dried on anhydrous magnesium sulfate
5. 5
   その他the solvent was removed by evaporation
6. 6
   その他to obtain a light yellow oily material
7. 7
   その他at room temperature
8. 8
   workup.ADDITIONwas added to the reaction mixture which
9. 9
   その他The resulting reaction solution
10. 10
    ろ過filtered through cerite,
11. 11
    その他followed by the removal of the solvent by evaporation
12. 12
    workup.DISSOLUTIONThe thus obtained colorless oily residue was dissolved in ether (10 ml)
13. 13
    抽出extracted with 2N hydrochloric acid (10 ml)
14. 14
    その他After removing the ether layer
15. 15
    その他the resulting reaction solution
16. 16
    抽出extracted with methylene chloride
17. 17
    その他the resulting organic layer was dried on potassium carbonate
18. 18
    その他the solvent was removed by evaporation
19. 19
    その他Thereafter, the resulting yellow oily residue was purified

実験手順

In an atmosphere of argon at room temperature, N-hydroxyethyl-4-methoxy-N-(2-methoxyphenyl)benzene sulfonamide (235 mg, 0.697 mmol) was dissolved in DMSO (3 ml) to which were subsequently added dropwise triethylamine (0.48 ml, 3.44 mmol) and sulfur trioxide-pyridine complex (558 mg, 3.44 mmol) which has been dissolved in DMSO (3 ml). After 20 minutes of stirring at the same temperature, ice water (10 ml) was added to the reaction solution, and the mixture was extracted with ethyl acetate and then washed with water and saturated brine. The resulting organic layer was dried on anhydrous magnesium sulfate, and the solvent was removed by evaporation to obtain a light yellow oily material. The thus obtained residue was dissolved in methanol (5 ml) to which were subsequently added 4-(4-fluorobenzoyl)piperidine (108 mg, 0.52 mmol) and molecular sieve 4A (200 mg) at room temperature. After 45 minutes of stirring at the same temperature, sodium cyanoborohydride (11 mg, 0.166 mmol) was added to the reaction mixture which was stirred for additional 30 minutes, followed by the addition of acetone (1 ml). The resulting reaction solution was diluted with ether (10 ml) and filtered through cerite, followed by the removal of the solvent by evaporation. The thus obtained colorless oily residue was dissolved in ether (10 ml) and extracted with 2N hydrochloric acid (10 ml). After removing the ether layer, the resulting reaction solution was adjusted to pH 9 to 10 with 10% sodium hydroxide aqueous solution and extracted with methylene chloride, the resulting organic layer was dried on potassium carbonate and then the solvent was removed by evaporation. Thereafter, the resulting yellow oily residue was purified by subjecting it to a silica gel column chromatography and PTLC (ether:hexane=7:1) to obtain 56.7 mg (15.4%) of the title compound in the form of colorless oil.

出典