反応 #2556

反応方程式

4-(4-Fluorobenzoyl)piperidine

bromoacetoaldehyde diethylacetal

triethylamine

→

title compound

収率 25.0%

1-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine

収率 25.0%

溶媒

methylene chloride

反応条件

後処理

1. 1
   温度After 12 hours of heating
2. 2
   温度under reflux
3. 3
   その他the solvent was removed by evaporation
4. 4
   その他the resulting residue was purified

実験手順

4-(4-Fluorobenzoyl)piperidine (207 mg, 1.0 mmol) was dissolved in methylene chloride (5 ml) to which were subsequently added bromoacetoaldehyde diethylacetal (305 mg, 1.5 mmol) and triethylamine (0.5 ml). After 12 hours of heating under reflux, the solvent was removed by evaporation, and the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 81 mg (25.0%) of the title compound in the form of orange oil.

出典