反応 #2551

反応方程式

4-Chloromethyl-N-(2-methoxyphenyl)benzamide

methylamine

→

title compound

収率 100.0%

N-(2-Methoxyphenyl)-4-(methylamino)methylbenzamide

収率 100.0%

溶媒

dioxane

dioxane

反応条件

後処理

1. 1
   その他was removed by evaporation
2. 2
   workup.ADDITIONthe resulting residue was diluted with methylene chloride (10 ml)
3. 3
   乾燥After drying on anhydrous sodium carbonate
4. 4
   その他the solvent was removed by evaporation

実験手順

4-Chloromethyl-N-(2-methoxyphenyl)benzamide (400 mg, 1.45 mmol) was dissolved in dioxane (4 ml) and then mixed with 50% methylamine aqueous solution (4 ml) at room temperature. After 1 hour of stirring at the same temperature, dioxane was removed by evaporation, and the resulting residue was diluted with methylene chloride (10 ml). After drying on anhydrous sodium carbonate, the solvent was removed by evaporation to obtain 500 mg (100%) of the title compound in the form of colorless oil.

出典