反応 #2501404

反応方程式

4-Cyanoisophthalic acid dimethyl ester

4-cyanoisophthalic acid dimethyl ester

lithium hydroxide

HCl

→

4-cyanoisophthalic acid

溶媒

methanol

water

反応条件

後処理

1. 1
   抽出The solution was extracted with ethyl acetate
2. 2
   乾燥the combined extracts were dried over Na2SO4
3. 3
   その他Removal of solvent

実験手順

4-Cyanoisophthalic acid dimethyl ester 203 (1.70 g, 7.76 mmol) was dissolved in methanol (100 mL) and then treated with an aqueous solution of lithium hydroxide (2.0 g, 46.5 mmol) in 50 mL of water. The basic solution was stirred at ambient temperature for 1.5 hour. It was then poured into a 10% HCl solution. The solution was extracted with ethyl acetate and the combined extracts were dried over Na2SO4. Removal of solvent gave quantitative yield of 4-cyanoisophthalic acid 204: 1H NMR (400 MHz, CD3OD) δ 8.01 (d, J=8 Hz, 1H), 8.33 (dd, J=1.7 Hz, J=8 Hz, 1H), 8.73 (d, J=1.7 Hz, 1H).

出典