反応 #2492360

反応方程式

2-(4-acetylamino-phenoxy)-propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

63

収率 98.1%

2-(4-Amino-phenoxy)-propionic acid

収率 98.1%

溶媒

hydrochloric acid

反応条件

後処理

1. 1
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled in vacuum
2. 2
   ろ過filtered hot
3. 3
   ろ過filtered
4. 4
   その他dried

実験手順

To a mixture 2-(4-acetylamino-phenoxy)-propionic acid methyl ester 62 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 63 (240 grams, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

出典